TitleChaperone-mediated autophagy and endosomal microautophagy: Joint by a chaperone.
Publication TypeJournal Article
Year of Publication2018
AuthorsTekirdag K, Cuervo AMaria
JournalJ Biol Chem
Volume293
Issue15
Pagination5414-5424
Date Published2018 Apr 13
ISSN1083-351X
Abstract

A variety of mechanisms deliver cytosolic materials to the lysosomal compartment for degradation through autophagy. Here, we focus on two autophagic pathways, the chaperone-mediated autophagy and the endosomal microautophagy that rely on the cytosolic chaperone hsc70 for substrate targeting. Although hsc70 participates in the triage of proteins for degradation by different proteolytic systems, the common characteristic shared by these two forms of autophagy is that hsc70 binds directly to a specific five-amino acid motif in the cargo protein for its autophagic targeting. We summarize the current understanding of the molecular machineries behind each of these types of autophagy.

DOI10.1074/jbc.R117.818237
Alternate JournalJ. Biol. Chem.
PubMed ID29247007
PubMed Central IDPMC5900761
Grant ListU54 NS100717 / NS / NINDS NIH HHS / United States
R01 AG021904 / AG / NIA NIH HHS / United States
P30 DK041296 / DK / NIDDK NIH HHS / United States
R37 AG021904 / AG / NIA NIH HHS / United States
RF1 AG054108 / AG / NIA NIH HHS / United States
P30 AG038072 / AG / NIA NIH HHS / United States
R01 DK098408 / DK / NIDDK NIH HHS / United States
P01 AG031782 / AG / NIA NIH HHS / United States