TitleA CRISPR Approach to Neurodegenerative Diseases.
Publication TypeJournal Article
Year of Publication2017
AuthorsKampmann M
JournalTrends Mol Med
Volume23
Issue6
Pagination483-485
Date Published2017 06
ISSN1471-499X
KeywordsAnimals, Cell Differentiation, CRISPR-Cas Systems, Humans, Induced Pluripotent Stem Cells, Neurodegenerative Diseases, Neurons
Abstract

A major barrier to developing effective therapies for neurodegenerative diseases is our incomplete understanding of the underlying cellular mechanisms. Genetic screens in human-induced pluripotent stem cell-derived neurons can elucidate such mechanisms. Genome-wide screens using CRISPR interference and CRISPR activation provide complementary biological insights and may reveal potential therapeutic targets.

DOI10.1016/j.molmed.2017.04.003
Alternate JournalTrends Mol Med
PubMed ID28478951
PubMed Central IDPMC5604856
Grant ListDP2 GM119139 / GM / NIGMS NIH HHS / United States
U54 NS100717 / NS / NINDS NIH HHS / United States