TitleCritical data-based re-evaluation of minocycline as a putative specific microglia inhibitor.
Publication TypeJournal Article
Year of Publication2016
AuthorsMöller T, Bard F, Bhattacharya A, Biber K, Campbell B, Dale E, Eder C, Gan L, Garden GA, Hughes ZA, Pearse DD, Staal RGW, Sayed FA, Wes PD, Boddeke HWGM
JournalGlia
Volume64
Issue10
Pagination1788-94
Date Published2016 10
ISSN1098-1136
KeywordsAnimals, Anti-Bacterial Agents, Databases, Factual, Humans, Microglia, Minocycline
Abstract

Minocycline, a second generation broad-spectrum antibiotic, has been frequently postulated to be a "microglia inhibitor." A considerable number of publications have used minocycline as a tool and concluded, after achieving a pharmacological effect, that the effect must be due to "inhibition" of microglia. It is, however, unclear how this "inhibition" is achieved at the molecular and cellular levels. Here, we weigh the evidence whether minocycline is indeed a bona fide microglia inhibitor and discuss how data generated with minocycline should be interpreted. GLIA 2016;64:1788-1794.

DOI10.1002/glia.23007
Alternate JournalGlia
PubMed ID27246804