|Title||Critical data-based re-evaluation of minocycline as a putative specific microglia inhibitor.|
|Publication Type||Journal Article|
|Year of Publication||2016|
|Authors||Möller T, Bard F, Bhattacharya A, Biber K, Campbell B, Dale E, Eder C, Gan L, Garden GA, Hughes ZA, Pearse DD, Staal RGW, Sayed FA, Wes PD, Boddeke HWGM|
|Date Published||2016 10|
|Keywords||Animals, Anti-Bacterial Agents, Databases, Factual, Humans, Microglia, Minocycline|
Minocycline, a second generation broad-spectrum antibiotic, has been frequently postulated to be a "microglia inhibitor." A considerable number of publications have used minocycline as a tool and concluded, after achieving a pharmacological effect, that the effect must be due to "inhibition" of microglia. It is, however, unclear how this "inhibition" is achieved at the molecular and cellular levels. Here, we weigh the evidence whether minocycline is indeed a bona fide microglia inhibitor and discuss how data generated with minocycline should be interpreted. GLIA 2016;64:1788-1794.