TitleEgocentric and allocentric visuospatial working memory in premotor Huntington's disease: A double dissociation with caudate and hippocampal volumes.
Publication TypeJournal Article
Year of Publication2017
AuthorsPossin KL, Kim H, Geschwind MD, Moskowitz T, Johnson ET, Sha SJ, Apple A, Xu D, Miller BL, Finkbeiner S, Hess CP, Kramer JH
JournalNeuropsychologia
Volume101
Pagination57-64
Date Published2017 Jul 01
ISSN1873-3514
KeywordsAdult, Algorithms, Analysis of Variance, Caudate Nucleus, Female, Hippocampus, Humans, Huntington Disease, Imaging, Three-Dimensional, Magnetic Resonance Imaging, Male, Memory, Short-Term, Middle Aged, Neuropsychological Tests, Organ Size, Self Concept, Social Perception, Spatial Memory, Visual Perception
Abstract

Our brains represent spatial information in egocentric (self-based) or allocentric (landmark-based) coordinates. Rodent studies have demonstrated a critical role for the caudate in egocentric navigation and the hippocampus in allocentric navigation. We administered tests of egocentric and allocentric working memory to individuals with premotor Huntington's disease (pmHD), which is associated with early caudate nucleus atrophy, and controls. Each test had 80 trials during which subjects were asked to remember 2 locations over 1-sec delays. The only difference between these otherwise identical tests was that locations could only be coded in self-based or landmark-based coordinates. We applied a multiatlas-based segmentation algorithm and computed point-wise Jacobian determinants to measure regional variations in caudate and hippocampal volumes from 3T MRI. As predicted, the pmHD patients were significantly more impaired on egocentric working memory. Only egocentric accuracy correlated with caudate volumes, specifically the dorsolateral caudate head, right more than left, a region that receives dense efferents from dorsolateral prefrontal cortex. In contrast, only allocentric accuracy correlated with hippocampal volumes, specifically intermediate and posterior regions that connect strongly with parahippocampal and posterior parietal cortices. These results indicate that the distinction between egocentric and allocentric navigation applies to working memory. The dorsolateral caudate is important for egocentric working memory, which can explain the disproportionate impairment in pmHD. Allocentric working memory, in contrast, relies on the hippocampus and is relatively spared in pmHD.

DOI10.1016/j.neuropsychologia.2017.04.022
Alternate JournalNeuropsychologia
PubMed ID28427989
PubMed Central IDPMC5765862
Grant ListP50 AG023501 / AG / NIA NIH HHS / United States
P01 AG017586 / AG / NIA NIH HHS / United States
K23 AG037566 / AG / NIA NIH HHS / United States
L30 RR024974 / RR / NCRR NIH HHS / United States
R01 AG032289 / AG / NIA NIH HHS / United States