TitleEvolution of New miRNAs and Cerebro-Cortical Development.
Publication TypeJournal Article
Year of Publication2018
AuthorsKosik KS, Nowakowski T
JournalAnnu Rev Neurosci
Date Published2018 Apr 04
ISSN1545-4126
Abstract

The noncoding portion of the genome, including microRNAs, has been fertile evolutionary soil for cortical development in primates. A major contribution to cortical expansion in primates is the generation of novel precursor cell populations. Because miRNA expression profiles track closely with cell identity, it is likely that numerous novel microRNAs have contributed to cellular diversity in the brain. The tools to determine the genomic context within which novel microRNAs emerge and how they become integrated into molecular circuitry are now in hand. Expected final online publication date for the Annual Review of Neuroscience Volume 41 is July 8, 2018. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

DOI10.1146/annurev-neuro-080317-061822
Alternate JournalAnnu. Rev. Neurosci.
PubMed ID29618285