TitleFrontotemporal Dementia.
Publication TypeJournal Article
Year of Publication2017
AuthorsOlney NT, Spina S, Miller BL
JournalNeurol Clin
Volume35
Issue2
Pagination339-374
Date Published2017 May
ISSN1557-9875
KeywordsBrain, Frontotemporal Dementia, History, 20th Century, Humans, Supranuclear Palsy, Progressive
Abstract

Frontotemporal dementia (FTD) is a heterogeneous disorder with distinct clinical phenotypes associated with multiple neuropathologic entities. Presently, the term FTD encompasses clinical disorders that include changes in behavior, language, executive control, and often motor symptoms. The core FTD spectrum disorders include behavioral variant FTD, nonfluent/agrammatic variant primary progressive aphasia, and semantic variant PPA. Related FTD disorders include frontotemporal dementia with motor neuron disease, progressive supranuclear palsy syndrome, and corticobasal syndrome. In this article, the authors discuss the clinical presentation, diagnostic criteria, neuropathology, genetics, and treatments of these disorders.

DOI10.1016/j.ncl.2017.01.008
Alternate JournalNeurol Clin
PubMed ID28410663
PubMed Central IDPMC5472209
Grant ListK08 AG052648 / AG / NIA NIH HHS / United States
P01 AG019724 / AG / NIA NIH HHS / United States
P50 AG023501 / AG / NIA NIH HHS / United States
T32 AG023481 / AG / NIA NIH HHS / United States