|Publication Type||Journal Article|
|Year of Publication||2018|
|Authors||Deleon J, Miller BL|
|Journal||Handb Clin Neurol|
Frontotemporal dementia (FTD) is a neurodegenerative disorder characterized by progressive changes in behavior, personality, and language with involvement of the frontal and temporal regions of the brain. About 40% of FTD cases have a positive family history, and about 10% of these cases are inherited in an autosomal-dominant pattern. These gene defects present with distinct clinical phenotypes. As the diagnosis of FTD becomes more recognizable, it will become increasingly important to keep these gene mutations in mind. In this chapter, we review the genes with known associations to FTD. We discuss protein functions, mutation frequencies, clinical phenotypes, imaging characteristics, and pathology associated with these genes.
|Alternate Journal||Handb Clin Neurol|
|Grant List||P01 AG019724 / AG / NIA NIH HHS / United States |
T32 AG023481 / AG / NIA NIH HHS / United States