TitleTREM2 and Amyloid Beta: A Love-Hate Relationship.
Publication TypeJournal Article
Year of Publication2018
AuthorsUdeochu J, Sayed FA, Gan L
JournalNeuron
Volume97
Issue5
Pagination991-993
Date Published2018 Mar 07
ISSN1097-4199
Abstract

Mutations in TREM2 increase risk for late-onset AD. In this issue of Neuron, Zhao et al. (2018) show that TREM2 binds Aβ to enhance its clearance and Lee et al. (2018) demonstrate that human TREM2 expression in AD mice ameliorates Aβ-associated deficits.

DOI10.1016/j.neuron.2018.02.018
Alternate JournalNeuron
PubMed ID29518360
Grant ListK12 GM081266 / GM / NIGMS NIH HHS / United States