Dr. Casey Cook is Co-PI of Core C (Human Validation Core). Dr. Cook (Core C) is an Assistant Professor in the Department of Neuroscience at Mayo Clinic Jacksonville, and her main research focus is understanding the mechanisms of neurodegeneration in tauopathies. Her efforts to develop a more versatile model of tauopathy utilizing somatic brain transgenesis have enabled the studies proposed in Project 2. In addition, she developed several tau immunoassays using the MesoScale Discovery platform, which will facilitate the high-throughput screening of large volumes of samples to identify mouse strains sensitive and resistant to tauopathy (Project 2). Her expertise in assay development and characterization will be essential to the activities of Core C, and she will work closely with Dr. Dickson to thoroughly investigate each target of interest to determine novel and informative endpoints that could be created to assess changes in function.