Dr. Leonard Petrucelli is the Center Director, Co-PI for Project 2, and PI of Core A (Administration Core). With his proven leadership as Chair of the Department of Neuroscience at the Mayo Clinic and director of a program project grant (NINDS) focused on pathomechanisms of the C9ORF72 repeat expansion, Dr. Petrucelli will guide the research focus and direction and our Center with assistance from the External Advisory Committee. Dr. Petrucelli has demonstrated scientific and administrative excellence and is uniquely positioned to lead and maintain the quality of the Projects and Cores. His laboratory has been at the forefront of research investigating cellular mechanisms that cause neurodegeneration in diseases characterized by abnormal protein aggregation, such as frontotemporal lobar degeneration (FTLD), amyotrophic lateral sclerosis (ALS), and Alzheimer’s disease (AD). In fact, Dr. Petrucelli was recently awarded a prestigious R35 Research Program Award (NINDS) in recognition of the strength and transformative nature of his program focused on the diverse underlying mechanisms of FTLD.