Publications

2018

Laks, D.R.; Oses-Prieto, J.A.; Alvarado, A.G.; Nakashima, J.; Chand, S.; Azzam, D.B.; Gholkar, A.A.; Sperry, J.; Ludwig, K.; Condro, M.C.; Nazarian, S.; Cardenas, A.; Shih, M.Y.S.; Damoiseaux, R.; France, B.; Orozco, N.; Visnyei, K.; Crisman, T.J.; Gao, F.; Torres, J.Z.; Coppola, G.; Burlingame, A.L.; Kornblum, H.I. A molecular cascade modulates MAP1B and confers resistance to mTOR inhibition in human glioblastoma. Neuro-oncology. 20 (6): 764-775. PMID: 29136244. PMCID: PMC5961175.
La Joie, R.; Bejanin, A.; Fagan, A.M.; Ayakta, N.; Baker, S.L.; Bourakova, V.; Boxer, A.L.; Cha, J.; Karydas, A.; Jerome, G.; Maass, A.; Mensing, A.; Miller, Z.A.; O'Neil, J.P.; Pham, J.; Rosen, H.J.; Tsai, R.; Visani, A.V.; Miller, B.L.; Jagust, W.J.; Rabinovici, G.D. Associations between [F]AV1451 tau PET and CSF measures of tau pathology in a clinical sample. Neurology. 90 (4): e282-e290. PMID: 29282337. PMCID: PMC5798657.
Amengual, J.; Guo, L.; Strong, A.; Madrigal-Matute, J.; Wang, H.; Kaushik, S.; Brodsky, J.L.; Rader, D.J.; Cuervo, A.Maria; Fisher, E.A. Autophagy Is Required for Sortilin-Mediated Degradation of Apolipoprotein B100. Circ. Res.. 122 (4): 568-582. PMID: 29301854. PMCID: PMC5815905.
Chen, J.; Coppola, G. Bioinformatics and genomic databases. Handb Clin Neurol. 147 75-92. PMID: 29325629.
Tekirdag, K.; Cuervo, A.Maria Chaperone-mediated autophagy and endosomal microautophagy: Joint by a chaperone. J. Biol. Chem.. 293 (15): 5414-5424. PMID: 29247007. PMCID: PMC5900761.
Gefen, T.; Ahmadian, S.S.; Mao, Q.; Kim, G.; Seckin, M.; Bonakdarpour, B.; Ramos, E.Marisa; Coppola, G.; Rademakers, R.; Rogalski, E.; Rademaker, A.; Weintraub, S.; Mesulam, M.M.; Geula, C.; Bigio, E.H. Combined Pathologies in FTLD-TDP Types A and C. J. Neuropathol. Exp. Neurol.. 77 (5): 405-412. PMID: 29584904.
Gola, K.A.; Thorne, A.; Veldhuisen, L.D.; Felix, C.M.; Hankinson, S.; Pham, J.; Shany-Ur, T.; Schauer, G.F.; Stanley, C.M.; Glenn, S.; Miller, B.L.; Rankin, K.P. Corrigendum to "Spontaneous narrative production in focal neurodegenerative disease" [Neuropsychologia 97 (2015) 158-171]. Neuropsychologia. 113 150. PMID: 29544696.
Brand, T.M.; Hartmann, S.; Bhola, N.E.; Li, H.; Zeng, Y.; O'Keefe, R.A.; Ranall, M.V.; Bandyopadhyay, S.; Soucheray, M.; Krogan, N.J.; Kemp, C.; Duvvuri, U.; LaVallee, T.; Johnson, D.E.; Ozbun, M.A.; Bauman, J.E.; Grandis, J.R. Cross-talk Signaling between HER3 and HPV16 E6 and E7 Mediates Resistance to PI3K Inhibitors in Head and Neck Cancer. Cancer Res.. 78 (9): 2383-2395. PMID: 29440171.
Rojas, J.C.; Bang, J.; Lobach, I.V.; Tsai, R.M.; Rabinovici, G.D.; Miller, B.L.; Boxer, A.L. CSF neurofilament light chain and phosphorylated tau 181 predict disease progression in PSP. Neurology. 90 (4): e273-e281. PMID: 29282336. PMCID: PMC5798651.
Bonham, L.W.; Karch, C.M.; Fan, C.C.; Tan, C.; Geier, E.G.; Wang, Y.; Wen, N.; Broce, I.J.; Li, Y.; Barkovich, M.J.; Ferrari, R.; Hardy, J.; Momeni, P.; Höglinger, G.; Müller, U.; Hess, C.P.; Sugrue, L.P.; Dillon, W.P.; Schellenberg, G.D.; Miller, B.L.; Andreassen, O.A.; Dale, A.M.; Barkovich, J.; Yokoyama, J.S.; Desikan, R.S. CXCR4 involvement in neurodegenerative diseases. Transl Psychiatry. 8 (1): 73. PMID: 29636460. PMCID: PMC5893558.
Seo, S.Won; Thibodeau, M.P.; Perry, D.C.; Hua, A.; Sidhu, M.; Sible, I.; Vargas, J.Norberto S.; Gaus, S.E.; Rabinovici, G.D.; Rankin, K.D.; Boxer, A.L.; Kramer, J.H.; Rosen, H.J.; Gorno-Tempini, M.Luisa; Grinberg, L.T.; Huang, E.J.; DeArmond, S.J.; Trojanowski, J.Q.; Miller, B.L.; Seeley, W.W. Early vs late age at onset frontotemporal dementia and frontotemporal lobar degeneration. Neurology. 90 (12): e1047-e1056. PMID: 29453245. PMCID: PMC5874448.
Lee, C.Y.Daniel; Daggett, A.; Gu, X.; Jiang, L.L.; Langfelder, P.; Li, X.; Wang, N.; Zhao, Y.; Park, C.Sin; Cooper, Y.; Ferando, I.; Mody, I.; Coppola, G.; Xu, H.; Yang, W. Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models. Neuron. 97 (5): 1032-1048.e5. PMID: 29518357. PMCID: PMC5927822.
Wang, C.; Telpoukhovskaia, M.A.; Bahr, B.A.; Chen, X.; Gan, L. Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases. Curr. Opin. Neurobiol.. 48 52-58. PMID: 29028540.
Kosik, K.S.; Nowakowski, T. Evolution of New miRNAs and Cerebro-Cortical Development. Annu. Rev. Neurosci.. PMID: 29618285.
Deleon, J.; Miller, B.L. Frontotemporal dementia. Handb Clin Neurol. 148 409-430. PMID: 29478591.
Wang, C.; Najm, R.; Xu, Q.; Jeong, D.E.; Walker, D.; Balestra, M.E.; Yoon, S.Yeon; Yuan, H.; Li, G.; Miller, Z.A.; Miller, B.L.; Malloy, M.J.; Huang, Y. Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector. Nat. Med.. 24 (5): 647-657. PMID: 29632371. PMCID: PMC5948154.
Roguev, A.; Ryan, C.J.; Hartsuiker, E.; Krogan, N.J. High-Throughput Quantitative Genetic Interaction Mapping in the Fission Yeast . Cold Spring Harb Protoc. 2018 (2): pdb.top079905. PMID: 28733404.
Gong, Z.; Tasset, I.; Diaz, A.; Anguiano, J.; Tas, E.; Cui, L.; Kuliawat, R.; Liu, H.; Kühn, B.; Cuervo, A.Maria; Muzumdar, R. Humanin is an endogenous activator of chaperone-mediated autophagy. J. Cell Biol.. 217 (2): 635-647. PMID: 29187525. PMCID: PMC5800795.
Zhang, H.; Freitas, D.; Kim, H.Sang; Fabijanic, K.; Li, Z.; Chen, H.; Mark, M.Tesic; Molina, H.; Martin, A.Benito; Bojmar, L.; Fang, J.; Rampersaud, S.; Hoshino, A.; Matei, I.; Kenific, C.M.; Nakajima, M.; Mutvei, A.Peter; Sansone, P.; Buehring, W.; Wang, H.; Jimenez, J.Pablo; Cohen-Gould, L.; Paknejad, N.; Brendel, M.; Manova-Todorova, K.; Magalhães, A.; Ferreira, J.Alexandre; Osório, H.; Silva, A.M.; Massey, A.; Cubillos-Ruiz, J.R.; Galletti, G.; Giannakakou, P.; Cuervo, A.Maria; Blenis, J.; Schwartz, R.; Brady, M.Sue; Peinado, H.; Bromberg, J.; Matsui, H.; Reis, C.A.; Lyden, D. Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation. Nat. Cell Biol.. 20 (3): 332-343. PMID: 29459780. PMCID: PMC5931706.
Petok, J.R.; Myers, C.E.; Pa, J.; Hobel, Z.; Wharton, D.M.; Medina, L.D.; Casado, M.; Coppola, G.; Gluck, M.A.; Ringman, J.M. Impairment of memory generalization in preclinical autosomal dominant Alzheimer's disease mutation carriers. Neurobiol. Aging. 65 149-157. PMID: 29494861. PMCID: PMC5871602.
Toller, G.; Brown, J.; Sollberger, M.; Shdo, S.M.; Bouvet, L.; Sukhanov, P.; Seeley, W.W.; Miller, B.L.; Rankin, K.P. Individual differences in socioemotional sensitivity are an index of salience network function. Cortex. 103 211-223. PMID: 29656245.
Caballero, B.; Wang, Y.; Diaz, A.; Tasset, I.; Juste, Y.Robert; Stiller, B.; Mandelkow, E.M.; Mandelkow, E.; Cuervo, A.Maria Interplay of pathogenic forms of human tau with different autophagic pathways. Aging Cell. 17 (1): PMID: 29024336. PMCID: PMC5770880.
Garrett, M.; Sperry, J.; Braas, D.; Yan, W.; Le, T.M.; Mottahedeh, J.; Ludwig, K.; Eskin, A.; Qin, Y.; Levy, R.; Breunig, J.J.; Pajonk, F.; Graeber, T.G.; Radu, C.G.; Christofk, H.; Prins, R.M.; Lai, A.; Liau, L.M.; Coppola, G.; Kornblum, H.I. Metabolic characterization of isocitrate dehydrogenase (IDH) mutant and IDH wildtype gliomaspheres uncovers cell type-specific vulnerabilities. Cancer Metab. 6 4. PMID: 29692895. PMCID: PMC5905129.
Jeng, M.Y.; Hull, P.A.; Fei, M.; Kwon, H.S.; Tsou, C.L.; Kasler, H.; Ng, C.P.; Gordon, D.E.; Johnson, J.; Krogan, N.; Verdin, E.; Ott, M. Metabolic reprogramming of human CD8 memory T cells through loss of SIRT1. J. Exp. Med.. 215 (1): 51-62. PMID: 29191913. PMCID: PMC5748845.
Langfelder, P.; Gao, F.; Wang, N.; Howland, D.; Kwak, S.; Vogt, T.F.; Aaronson, J.S.; Rosinski, J.; Coppola, G.; Horvath, S.; Yang, W. MicroRNA signatures of endogenous Huntingtin CAG repeat expansion in mice. PLoS ONE. 13 (1): e0190550. PMID: 29324753. PMCID: PMC5764268.
Martinez-Losa, M.; Tracy, T.E.; Ma, K.; Verret, L.; Clemente-Perez, A.; Khan, A.S.; Cobos, I.; Ho, K.; Gan, L.; Mucke, L.; Alvarez-Dolado, M.; Palop, J.J. Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease. Neuron. 98 (1): 75-89.e5. PMID: 29551491. PMCID: PMC5886814.
Tan, C.Hong; Fan, C.Chieh; Mormino, E.C.; Sugrue, L.P.; Broce, I.J.; Hess, C.P.; Dillon, W.P.; Bonham, L.W.; Yokoyama, J.S.; Karch, C.M.; Brewer, J.B.; Rabinovici, G.D.; Miller, B.L.; Schellenberg, G.D.; Kauppi, K.; Feldman, H.A.; Holland, D.; McEvoy, L.K.; Hyman, B.T.; Bennett, D.A.; Andreassen, O.A.; Dale, A.M.; Desikan, R.S. Polygenic hazard score: an enrichment marker for Alzheimer's associated amyloid and tau deposition. Acta Neuropathol.. 135 (1): 85-93. PMID: 29177679. PMCID: PMC5758038.
Miller, Z.A.; Rosenberg, L.; Santos-Santos, M.A.; Stephens, M.; Allen, I.E.; Hubbard, I.; Cantwell, A.; Mandelli, M.Luisa; Grinberg, L.T.; Seeley, W.W.; Miller, B.L.; Rabinovici, G.D.; Gorno-Tempini, M.Luisa Prevalence of Mathematical and Visuospatial Learning Disabilities in Patients With Posterior Cortical Atrophy. JAMA Neurol. 75 (6): 728-737. PMID: 29630699.
Theofilas, P.; Ehrenberg, A.J.; Nguy, A.; Thackrey, J.M.; Dunlop, S.; Mejia, M.B.; Alho, A.T.; Leite, R.Elaine Par; Rodriguez, R.Diehl; Suemoto, C.K.; Nascimento, C.F.; Chin, M.; Medina-Cleghorn, D.; Cuervo, A.Maria; Arkin, M.; Seeley, W.W.; Miller, B.L.; Nitrini, R.; Pasqualucci, C.Augusto; Filho, W.Jacob; Rueb, U.; Neuhaus, J.; Heinsen, H.; Grinberg, L.T. Probing the correlation of neuronal loss, neurofibrillary tangles, and cell death markers across the Alzheimer's disease Braak stages: a quantitative study in humans. Neurobiol. Aging. 61 1-12. PMID: 29031088. PMCID: PMC5705284.
Masand, R.; Paulo, E.; Wu, D.; Wang, Y.; Swaney, D.L.; Jimenez-Morales, D.; Krogan, N.J.; Wang, B. Proteome Imbalance of Mitochondrial Electron Transport Chain in Brown Adipocytes Leads to Metabolic Benefits. Cell Metab.. 27 (3): 616-629.e4. PMID: 29514069. PMCID: PMC6020063.
Yan, L.; Liu, C.Y.; Wong, K.P.; Huang, S.C.; Mack, W.J.; Jann, K.; Coppola, G.; Ringman, J.M.; Wang, D.J.J. Regional association of pCASL-MRI with FDG-PET and PiB-PET in people at risk for autosomal dominant Alzheimer's disease. Neuroimage Clin. 17 751-760. PMID: 29527482. PMCID: PMC5842754.
Min, S.W.; Sohn, P.Dongmin; Li, Y.; Devidze, N.; Johnson, J.R.; Krogan, N.J.; Masliah, E.; Mok, S.A.; Gestwicki, J.E.; Gan, L. SIRT1 Deacetylates Tau and Reduces Pathogenic Tau Spread in a Mouse Model of Tauopathy. J. Neurosci.. 38 (15): 3680-3688. PMID: 29540553. PMCID: PMC5895994.
Rauch, J.N.; Chen, J.J.; Sorum, A.W.; Miller, G.M.; Sharf, T.; See, S.K.; Hsieh-Wilson, L.C.; Kampmann, M.; Kosik, K.S. Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs). Sci Rep. 8 (1): 6382. PMID: 29686391. PMCID: PMC5913225.
Possin, K.L.; Moskowitz, T.; Erlhoff, S.J.; Rogers, K.M.; Johnson, E.T.; Steele, N.Z.R.; Higgins, J.J.; Stiver, J.; Alioto, A.G.; Farias, S.T.; Miller, B.L.; Rankin, K.P. The Brain Health Assessment for Detecting and Diagnosing Neurocognitive Disorders. J Am Geriatr Soc. 66 (1): 150-156. PMID: 29355911. PMCID: PMC5889617.
Kaushik, S.; Cuervo, A.Maria The coming of age of chaperone-mediated autophagy. Nat. Rev. Mol. Cell Biol.. 19 (6): 365-381. PMID: 29626215.
Udeochu, J.; Sayed, F.A.; Gan, L. TREM2 and Amyloid Beta: A Love-Hate Relationship. Neuron. 97 (5): 991-993. PMID: 29518360.

2017

Judge, L.M.; Perez-Bermejo, J.A.; Truong, A.; Ribeiro, A.Js; Yoo, J.C.; Jensen, C.L.; Mandegar, M.A.; Huebsch, N.; Kaake, R.M.; So, P.L.; Srivastava, D.; Pruitt, B.L.; Krogan, N.J.; Conklin, B.R. A BAG3 chaperone complex maintains cardiomyocyte function during proteotoxic stress. JCI Insight. 2 (14): PMID: 28724793. PMCID: PMC5518554.
Kampmann, M. A CRISPR Approach to Neurodegenerative Diseases. Trends Mol Med. 23 (6): 483-485. PMID: 28478951. PMCID: PMC5604856.
Park, R.J.; Wang, T.; Koundakjian, D.; Hultquist, J.F.; Lamothe-Molina, P.; Monel, B.; Schumann, K.; Yu, H.; Krupzcak, K.M.; Garcia-Beltran, W.; Piechocka-Trocha, A.; Krogan, N.J.; Marson, A.; Sabatini, D.M.; Lander, E.S.; Hacohen, N.; Walker, B.D. A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors. Nat. Genet.. 49 (2): 193-203. PMID: 27992415. PMCID: PMC5511375.
Spina, E.J.; Guzman, E.; Zhou, H.; Kosik, K.S.; Smith, W.C. A microRNA-mRNA expression network during oral siphon regeneration in . Development. 144 (10): 1787-1797. PMID: 28432214. PMCID: PMC5450834.

2018

2017

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