Publications

2017

Sun, G.; Guzman, E.; Balasanyan, V.; Conner, C.M.; Wong, K.; Zhou, H.Robin; Kosik, K.S.; Montell, D.J. A molecular signature for anastasis, recovery from the brink of apoptotic cell death. J. Cell Biol.. 216 (10): 3355-3368. PMID: 28768686. PMCID: PMC5626555.
Ranasinghe, K.G.; Gill, J.S.; Kothare, H.; Beagle, A.J.; Mizuiri, D.; Honma, S.M.; Gorno-Tempini, M.Luisa; Miller, B.L.; Vossel, K.A.; Nagarajan, S.S.; Houde, J.F. Abnormal vocal behavior predicts executive and memory deficits in Alzheimer's disease. Neurobiol. Aging. 52 71-80. PMID: 28131013. PMCID: PMC5359035.
Tracy, T.E.; Gan, L. Acetylated tau in Alzheimer's disease: An instigator of synaptic dysfunction underlying memory loss: Increased levels of acetylated tau blocks the postsynaptic signaling required for plasticity and promotes memory deficits associated with tauopathy. Bioessays. 39 (4): PMID: 28083916. PMCID: PMC5903676.
Fontes, M.M.; Guvenek, A.; Kawaguchi, R.; Zheng, D.; Huang, A.; Ho, V.M.; Chen, P.B.; Liu, X.; O'Dell, T.J.; Coppola, G.; Tian, B.; Martin, K.C. Activity-Dependent Regulation of Alternative Cleavage and Polyadenylation During Hippocampal Long-Term Potentiation. Sci Rep. 7 (1): 17377. PMID: 29234016. PMCID: PMC5727029.
Sha, S.J.; Miller, Z.A.; Min, S.W.; Zhou, Y.; Brown, J.; Mitic, L.L.; Karydas, A.; Koestler, M.; Tsai, R.; Corbetta-Rastelli, C.; Lin, S.; Hare, E.; Fields, S.; Fleischmann, K.E.; Powers, R.; Fitch, R.; Martens, L.Herl; Shamloo, M.; Fagan, A.M.; Farese, R.V.; Pearlman, R.; Seeley, W.; Miller, B.L.; Gan, L.; Boxer, A.L. An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from gene mutations. Alzheimers Dement (N Y). 3 (4): 507-512. PMID: 29124108. PMCID: PMC5671622.
Lobingier, B.T.; Hüttenhain, R.; Eichel, K.; Miller, K.B.; Ting, A.Y.; von Zastrow, M.; Krogan, N.J. An Approach to Spatiotemporally Resolve Protein Interaction Networks in Living Cells. Cell. 169 (2): 350-360.e12. PMID: 28388416. PMCID: PMC5616215.
Boselli, M.; Lee, B.H.; Robert, J.; Prado, M.A.; Min, S.W.; Cheng, C.; Silva, C.; Seong, C.; Elsasser, S.; Hatle, K.M.; Gahman, T.C.; Gygi, S.P.; Haggarty, S.J.; Gan, L.; King, R.W.; Finley, D. An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons. J. Biol. Chem.. 292 (47): 19209-19225. PMID: 28972160. PMCID: PMC5702663.
Alegro, M.; Theofilas, P.; Nguy, A.; Castruita, P.A.; Seeley, W.; Heinsen, H.; Ushizima, D.M.; Grinberg, L.T. Automating cell detection and classification in human brain fluorescent microscopy images using dictionary learning and sparse coding. J. Neurosci. Methods. 282 20-33. PMID: 28267565. PMCID: PMC5600818.
Gomes, L.R.; Menck, C.F.M.; Cuervo, A.Maria Chaperone-mediated autophagy prevents cellular transformation by regulating MYC proteasomal degradation. Autophagy. 13 (5): 928-940. PMID: 28410006. PMCID: PMC5446085.
Perry, D.C.; Brown, J.A.; Possin, K.L.; Datta, S.; Trujillo, A.; Radke, A.; Karydas, A.; Kornak, J.; Sias, A.C.; Rabinovici, G.D.; Gorno-Tempini, M.Luisa; Boxer, A.L.; De May, M.; Rankin, K.P.; Sturm, V.E.; Lee, S.E.; Matthews, B.R.; Kao, A.W.; Vossel, K.A.; Tartaglia, M.Carmela; Miller, Z.A.; Seo, S.Won; Sidhu, M.; Gaus, S.E.; Nana, A.L.; Vargas, J.Norberto S.; Hwang, J.H.L.; Ossenkoppele, R.; Brown, A.B.; Huang, E.J.; Coppola, G.; Rosen, H.J.; Geschwind, D.; Trojanowski, J.Q.; Grinberg, L.T.; Kramer, J.H.; Miller, B.L.; Seeley, W.W. Clinicopathological correlations in behavioural variant frontotemporal dementia. Brain. 140 (12): 3329-3345. PMID: 29053860. PMCID: PMC5841140.
Jost, M.; Chen, Y.; Gilbert, L.A.; Horlbeck, M.A.; Krenning, L.; Menchon, G.; Rai, A.; Cho, M.Y.; Stern, J.J.; Prota, A.E.; Kampmann, M.; Akhmanova, A.; Steinmetz, M.O.; Tanenbaum, M.E.; Weissman, J.S. Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent. Mol. Cell. 68 (1): 210-223.e6. PMID: 28985505. PMCID: PMC5640507.
Nagy, T.; Kampmann, M. CRISPulator: a discrete simulation tool for pooled genetic screens. BMC Bioinformatics. 18 (1): 347. PMID: 28732459. PMCID: PMC5521134.
Zhang, J.; Johnson, J.L.; He, J.; Napolitano, G.; Ramadass, M.; Rocca, C.; Kiosses, W.B.; Bucci, C.; Xin, Q.; Gavathiotis, E.; Cuervo, A.Maria; Cherqui, S.; Catz, S.D. Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A. J. Biol. Chem.. 292 (25): 10328-10346. PMID: 28465352. PMCID: PMC5481548.
Shdo, S.M.; Ranasinghe, K.G.; Gola, K.A.; Mielke, C.J.; Sukhanov, P.V.; Miller, B.L.; Rankin, K.P. Deconstructing empathy: Neuroanatomical dissociations between affect sharing and prosocial motivation using a patient lesion model. Neuropsychologia. PMID: 28209520. PMCID: PMC5773395.
Possin, K.L.; Merrilees, J.; Bonasera, S.J.; Bernstein, A.; Chiong, W.; Lee, K.; Wilson, L.; Hooper, S.M.; Dulaney, S.; Braley, T.; Laohavanich, S.; Feuer, J.E.; Clark, A.M.; Schaffer, M.W.; Schenk, K.; Heunis, J.; Ong, P.; Cook, K.M.; Bowhay, A.D.; Gearhart, R.; Chodos, A.; Naasan, G.; Bindman, A.B.; Dohan, D.; Ritchie, C.; Miller, B.L. Development of an adaptive, personalized, and scalable dementia care program: Early findings from the Care Ecosystem. PLoS Med.. 14 (3): e1002260. PMID: 28323819. PMCID: PMC5360211.
Possin, K.L.; Kim, H.; Geschwind, M.D.; Moskowitz, T.; Johnson, E.T.; Sha, S.J.; Apple, A.; Xu, D.; Miller, B.L.; Finkbeiner, S.; Hess, C.P.; Kramer, J.H. Egocentric and allocentric visuospatial working memory in premotor Huntington's disease: A double dissociation with caudate and hippocampal volumes. Neuropsychologia. 101 57-64. PMID: 28427989. PMCID: PMC5765862.
Kampmann, M. Elucidating drug targets and mechanisms of action by genetic screens in mammalian cells. Chem. Commun. (Camb.). 53 (53): 7162-7167. PMID: 28487920. PMCID: PMC5507204.
Lisi, V.; Singh, B.; Giroux, M.; Guzman, E.; Painter, M.W.; Cheng, Y.C.; Huebner, E.; Coppola, G.; Costigan, M.; Woolf, C.J.; Kosik, K.S. Enhanced Neuronal Regeneration in the CAST/Ei Mouse Strain Is Linked to Expression of Differentiation Markers after Injury. Cell Rep. 20 (5): 1136-1147. PMID: 28768198. PMCID: PMC5565222.
Sigg, M.Abedin; Menchen, T.; Lee, C.; Johnson, J.; Jungnickel, M.K.; Choksi, S.P.; Garcia, G.; Busengdal, H.; Dougherty, G.W.; Pennekamp, P.; Werner, C.; Rentzsch, F.; Florman, H.M.; Krogan, N.; Wallingford, J.B.; Omran, H.; Reiter, J.F. Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways. Dev. Cell. 43 (6): 744-762.e11. PMID: 29257953. PMCID: PMC5752135.
Steele, N.Z.R.; Carr, J.S.; Bonham, L.W.; Geier, E.G.; Damotte, V.; Miller, Z.A.; Desikan, R.S.; Boehme, K.L.; Mukherjee, S.; Crane, P.K.; Kauwe, J.S.K.; Kramer, J.H.; Miller, B.L.; Coppola, G.; Hollenbach, J.A.; Huang, Y.; Yokoyama, J.S. Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case-control study. PLoS Med.. 14 (3): e1002272. PMID: 28350795. PMCID: PMC5369701.
Spina, S.; Schonhaut, D.R.; Boeve, B.F.; Seeley, W.W.; Ossenkoppele, R.; O'Neil, J.P.; Lazaris, A.; Rosen, H.J.; Boxer, A.L.; Perry, D.C.; Miller, B.L.; Dickson, D.W.; Parisi, J.E.; Jagust, W.J.; Murray, M.E.; Rabinovici, G.D. Frontotemporal dementia with the V337M mutation: Tau-PET and pathology correlations. Neurology. 88 (8): 758-766. PMID: 28130473. PMCID: PMC5344079.
Olney, N.T.; Spina, S.; Miller, B.L. Frontotemporal Dementia. Neurol Clin. 35 (2): 339-374. PMID: 28410663. PMCID: PMC5472209.
Tsvetanova, N.G.; Trester-Zedlitz, M.; Newton, B.W.; Riordan, D.P.; Sundaram, A.B.; Johnson, J.R.; Krogan, N.J.; von Zastrow, M. G Protein-Coupled Receptor Endocytosis Confers Uniformity in Responses to Chemically Distinct Ligands. Mol. Pharmacol.. 91 (2): 145-156. PMID: 27879340. PMCID: PMC5267521.
Chen, J.; Yu, J.T.; Wojta, K.; Wang, H.F.; Zetterberg, H.; Blennow, K.; Yokoyama, J.S.; Weiner, M.W.; Kramer, J.H.; Rosen, H.; Miller, B.L.; Coppola, G.; Boxer, A.L. Genome-wide association study identifies locus influencing human plasma tau levels. Neurology. 88 (7): 669-676. PMID: 28100725. PMCID: PMC5317386.
Ward, M.E.; Chen, R.; Huang, H.Y.; Ludwig, C.; Telpoukhovskaia, M.; Taubes, A.; Boudin, H.; Minami, S.S.; Reichert, M.; Albrecht, P.; Gelfand, J.M.; Cruz-Herranz, A.; Cordano, C.; Alavi, M.V.; Leslie, S.; Seeley, W.W.; Miller, B.L.; Bigio, E.; Mesulam, M.M.; Bogyo, M.S.; Mackenzie, I.R.; Staropoli, J.F.; Cotman, S.L.; Huang, E.J.; Gan, L.; Green, A.J. Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis. Sci Transl Med. 9 (385): PMID: 28404863. PMCID: PMC5526610.
Rauch, B.J.; Silvis, M.R.; Hultquist, J.F.; Waters, C.S.; McGregor, M.J.; Krogan, N.J.; Bondy-Denomy, J. Inhibition of CRISPR-Cas9 with Bacteriophage Proteins. Cell. 168 (1-2): 150-158.e10. PMID: 28041849. PMCID: PMC5235966.
Olney, N.T.; Alquezar, C.; Ramos, E.Marisa; Nana, A.L.; Fong, J.C.; Karydas, A.M.; Taylor, J.B.; Stephens, M.L.; Argouarch, A.R.; Van Berlo, V.A.; Dokuru, D.R.; Sherr, E.H.; Jicha, G.A.; Dillon, W.P.; Desikan, R.S.; De May, M.; Seeley, W.W.; Coppola, G.; Miller, B.L.; Kao, A.W. Linking tuberous sclerosis complex, excessive mTOR signaling, and age-related neurodegeneration: a new association between TSC1 mutation and frontotemporal dementia. Acta Neuropathol.. 134 (5): 813-816. PMID: 28828560. PMCID: PMC5645431.
Theofilas, P.; Ehrenberg, A.J.; Dunlop, S.; Alho, A.T.Di Loren; Nguy, A.; Leite, R.Elaine Par; Rodriguez, R.Diehl; Mejia, M.B.; Suemoto, C.K.; Ferretti-Rebustini, R.Eloah De L.; Polichiso, L.; Nascimento, C.F.; Seeley, W.W.; Nitrini, R.; Pasqualucci, C.Augusto; Filho, W.Jacob; Rueb, U.; Neuhaus, J.; Heinsen, H.; Grinberg, L.T. Locus coeruleus volume and cell population changes during Alzheimer's disease progression: A stereological study in human postmortem brains with potential implication for early-stage biomarker discovery. Alzheimers Dement. 13 (3): 236-246. PMID: 27513978. PMCID: PMC5298942.
Krabbe, G.; Minami, S.; Etchegaray, J.I.; Taneja, P.; Djukic, B.; Davalos, D.; Le, D.; Lo, I.; Zhan, L.; Reichert, M.C.; Sayed, F.; Merlini, M.; Ward, M.E.; Perry, D.C.; Lee, S.E.; Sias, A.; Parkhurst, C.N.; Gan, W.B.; Akassoglou, K.; Miller, B.L.; Farese, R.V.; Gan, L. Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia. Proc. Natl. Acad. Sci. U.S.A.. 114 (19): 5029-5034. PMID: 28438992. PMCID: PMC5441749.
Scherling, C.S.; Zakrzewski, J.; Datta, S.; Levenson, R.W.; Shimamura, A.P.; Sturm, V.E.; Miller, B.L.; Rosen, H.J. Mistakes, Too Few to Mention? Impaired Self-conscious Emotional Processing of Errors in the Behavioral Variant of Frontotemporal Dementia. Front Behav Neurosci. 11 189. PMID: 29089874. PMCID: PMC5651000.
Galluzzi, L.; Baehrecke, E.H.; Ballabio, A.; Boya, P.; San Pedro, J.Manuel Bra; Cecconi, F.; Choi, A.M.; Chu, C.T.; Codogno, P.; Colombo, M.Isabel; Cuervo, A.Maria; Debnath, J.; Deretic, V.; Dikic, I.; Eskelinen, E.L.; Fimia, G.Maria; Fulda, S.; Gewirtz, D.A.; Green, D.R.; Hansen, M.; Harper, W.; Jäättelä, M.; Johansen, T.; Juhasz, G.; Kimmelman, A.C.; Kraft, C.; Ktistakis, N.T.; Kumar, S.; Levine, B.; Lopez-Otin, C.; Madeo, F.; Martens, S.; Martinez, J.; Melendez, A.; Mizushima, N.; Münz, C.; Murphy, L.O.; Penninger, J.M.; Piacentini, M.; Reggiori, F.; Rubinsztein, D.C.; Ryan, K.M.; Santambrogio, L.; Scorrano, L.; Simon, A.Katharina; Simon, H.U.; Simonsen, A.; Tavernarakis, N.; Tooze, S.A.; Yoshimori, T.; Yuan, J.; Yue, Z.; Zhong, Q.; Kroemer, G. Molecular definitions of autophagy and related processes. EMBO J.. 36 (13): 1811-1836. PMID: 28596378. PMCID: PMC5494474.
Goetzl, E.J.; Miller, B.L. Multicellular hypothesis for the pathogenesis of Alzheimer's disease. FASEB J.. 31 (5): 1792-1795. PMID: 28100644.
Chai, H.; Diaz-Castro, B.; Shigetomi, E.; Monte, E.; Octeau, C.; Yu, X.; Cohn, W.; Rajendran, P.S.; Vondriska, T.M.; Whitelegge, J.P.; Coppola, G.; Khakh, B.S. Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence. Neuron. 95 (3): 531-549.e9. PMID: 28712653. PMCID: PMC5811312.
Pressman, P.S.; Simpson, M.; Gola, K.; Shdo, S.M.; Spinelli, E.G.; Miller, B.L.; Gorno-Tempini, M.Luisa; Rankin, K.; Levenson, R.W. Observing conversational laughter in frontotemporal dementia. J. Neurol. Neurosurg. Psychiatry. 88 (5): 418-424. PMID: 28235777. PMCID: PMC5726511.
Esteban-Martínez, L.; Sierra-Filardi, E.; McGreal, R.S.; Salazar-Roa, M.; Mariño, G.; Seco, E.; Durand, S.; Enot, D.; Graña, O.; Malumbres, M.; Cvekl, A.; Cuervo, A.Maria; Kroemer, G.; Boya, P. Programmed mitophagy is essential for the glycolytic switch during cell differentiation. EMBO J.. 36 (12): 1688-1706. PMID: 28465321. PMCID: PMC5470043.
Huang, A.Y.; Yu, D.; Davis, L.K.; Sul, J.Hoon; Tsetsos, F.; Ramensky, V.; Zelaya, I.; Ramos, E.Marisa; Osiecki, L.; Chen, J.A.; McGrath, L.M.; Illmann, C.; Sandor, P.; Barr, C.L.; Grados, M.; Singer, H.S.; Nöthen, M.M.; Hebebrand, J.; King, R.A.; Dion, Y.; Rouleau, G.; Budman, C.L.; Depienne, C.; Worbe, Y.; Hartmann, A.; Müller-Vahl, K.R.; Stuhrmann, M.; Aschauer, H.; Stamenkovic, M.; Schloegelhofer, M.; Konstantinidis, A.; Lyon, G.J.; McMahon, W.M.; Barta, C.; Tarnok, Z.; Nagy, P.; Batterson, J.R.; Rizzo, R.; Cath, D.C.; Wolanczyk, T.; Berlin, C.; Malaty, I.A.; Okun, M.S.; Woods, D.W.; Rees, E.; Pato, C.N.; Pato, M.T.; Knowles, J.A.; Posthuma, D.; Pauls, D.L.; Cox, N.J.; Neale, B.M.; Freimer, N.B.; Paschou, P.; Mathews, C.A.; Scharf, J.M.; Coppola, G. Rare Copy Number Variants in NRXN1 and CNTN6 Increase Risk for Tourette Syndrome. Neuron. 94 (6): 1101-1111.e7. PMID: 28641109. PMCID: PMC5568251.
Wang, C.; Ward, M.E.; Chen, R.; Liu, K.; Tracy, T.E.; Chen, X.; Xie, M.; Sohn, P.Dongmin; Ludwig, C.; Meyer-Franke, A.; Karch, C.M.; Ding, S.; Gan, L. Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening. Stem Cell Reports. 9 (4): 1221-1233. PMID: 28966121. PMCID: PMC5639430.
Watanabe, M.; Buth, J.E.; Vishlaghi, N.; de la Torre-Ubieta, L.; Taxidis, J.; Khakh, B.S.; Coppola, G.; Pearson, C.A.; Yamauchi, K.; Gong, D.; Dai, X.; Damoiseaux, R.; Aliyari, R.; Liebscher, S.; Schenke-Layland, K.; Caneda, C.; Huang, E.J.; Zhang, Y.; Cheng, G.; Geschwind, D.H.; Golshani, P.; Sun, R.; Novitch, B.G. Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection. Cell Rep. 21 (2): 517-532. PMID: 29020636. PMCID: PMC5637483.
Yokoyama, J.S.; Karch, C.M.; Fan, C.C.; Bonham, L.W.; Kouri, N.; Ross, O.A.; Rademakers, R.; Kim, J.; Wang, Y.; Höglinger, G.U.; Müller, U.; Ferrari, R.; Hardy, J.; Momeni, P.; Sugrue, L.P.; Hess, C.P.; Barkovich, J.; Boxer, A.L.; Seeley, W.W.; Rabinovici, G.D.; Rosen, H.J.; Miller, B.L.; Schmansky, N.J.; Fischl, B.; Hyman, B.T.; Dickson, D.W.; Schellenberg, G.D.; Andreassen, O.A.; Dale, A.M.; Desikan, R.S. Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia. Acta Neuropathol.. 133 (5): 825-837. PMID: 28271184. PMCID: PMC5429027.
Boehm, D.; Jeng, M.; Camus, G.; Gramatica, A.; Schwarzer, R.; Johnson, J.R.; Hull, P.A.; Montano, M.; Sakane, N.; Pagans, S.; Godin, R.; Deeks, S.G.; Krogan, N.J.; Greene, W.C.; Ott, M. SMYD2-Mediated Histone Methylation Contributes to HIV-1 Latency. Cell Host Microbe. 21 (5): 569-579.e6. PMID: 28494238. PMCID: PMC5490666.

2017

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