Dr. Ana Maria Cuervo is the principal investigator for project 3. Dr. Cuervo is a professor at Albert Einstein College of Medicine and a world expert in autophagy. Dr. Cuervo’s lab identified the molecular machinery that mediates translocation of substrates into lysosomes via chaperone-mediated autophagy (CMA). She also discovered a new type of autophagy, endosomal microautophagy (e-Mi), which represents a new site of interaction between endocytic and autophagic pathways, and a connection between autophagy and exosome biogenesis and extracellular release.