Dr. Ken Kosik is the principal investigator for project 2. Dr. Kosik, a professor at the University of California, Santa Barbara, has made important discoveries in Tau pathobiology and stem cell biology. At the beginning of his career, Dr. Kosik was among the first to describe tau protein in Alzheimer neurofibrillary tangles. Those early studies led to the cloning of human tau, the first description of developmentally-regulated tau splicing, the role of tau in neuronal polarity, and the first identification of the tau E3 ligase. Dr. Kosik has also made important discoveries in stem cell biology using system-based approaches.