Dr. Nevan Krogan is a senior investigator at the Gladstone Institutes and the director of the Quantitative Biosciences Institute at the University of California, San Francisco. He also oversees the Mass Spectrometry technology center at Gladstone. Dr. Krogan’s laboratory focuses on the development of novel mass spectrometry¬–based approaches, genetic interaction screening platforms, and computational tools for data analysis. His team’s findings have provided unprecedented insights into the function, structure, and mechanisms of many molecular networks and pathways. Using an affinity purification-MS (AP-MS) strategy, they comprehensively characterized HIV-human protein-protein interactions (PPIs). Additionally, they developed a new algorithm, MIST, for scoring PPIs. Apart from PPIs, the lab pioneered the characterization of multiple post-translational modifications (PTMs) in a global, unbiased manner. They also developed other new computational tools for studying PTMs. One example is PTMFunc, which prioritizes PTMs by their likelihood of being functionally important based on location at protein-protein interfaces, evolutionary conservation, and proximity to other regulated modifications.